bet sizing strategies are a function of ranges, position, and SPR.
in terms of range advantage, i open 2x preflop, his defense range is quite wide because of this, but doesn't include any offsuit 2 pairs probably, (maybe 46o). The only strong hands he has are suited 2pairs and and sets. I have JJ-AA, and sets. and due to SPR, i can put quite a bit of money in on flop, and i want to, because of this range advantage.
If he only had top pair as best hand on this flop and i was 10,000bb deep, i could 10x pot flop with JJ+ and be fine